Notable achievements
The history of CALS is replete with achievements that have changed the university, the state and the world. From the groundbreaking discovery of Vitamin A to the crucial mass production of penicillin during World War II, CALS scientists, researchers and faculty have always pushed the envelope of cutting-edge innovation. Below are just a few of the amazing discoveries made by those housed within one of the nation’s pre-eminent agricultural colleges.
Information is also available in this PDF of notable dates in the history of CALS, which was published in January, 1989.
- 1890 – Agricultural chemist Stephen Babcock develops test to measure butterfat content in milk. Buyers can now pay farmers according to the fat content of their milk.
- 1894 – No more exploding peas: Bacteriologist Harry Russell develops new, higher-temperature sterilization methods for canned peas and other vegetables, changing industry practices nation-wide.
- 1909 – Nation’s first department of agricultural economics founded at CALS.
- 1910 – Department of what? The college establishes the nation’s first department of genetics, but called it “experimental breeding,” because certain ag leaders doubted that farmers would understand what “genetics” meant.
- 1911 – Charles Galpin is the nation’s first professor of rural sociology. His research on Walworth County established the field.
- 1911 – Plant pathologist J.C. Walker developed strains of cabbage resistant to a fungus that was threatening Wisconsin’s entire crop. This spawned the later development of disease resistance in onions, potatoes, beans, peas and cucumbers.
- 1912 – Two-wheeled agent. College teams with Oneida Co. to hire Wisconsin’s first county ag agent. E.L. Luther visits farms by motorcycle.
- 1913 – CALS biochemists discovered the first vitamin, A, in 1913. Two years later they discovered the vitamin B complex, which opened the field of nutrition for the identification of all the vitamins in the 1940s.
- 1919 – “Hello to all you farmers.” Ag information from the college serves as the content for the nation’s first regular radio broadcasts.
- 1923 – Biochemist Harry Steenbock figures out how to biofortify food with vitamin D by exposing it to ultraviolet light, leading to the almost complete eradication of rickets by the mid-1940s. Also, the college names Prof. O.R. Zeasman as the nation’s first soil erosion specialist.
- 1932 – College hires John Steuart Curry as artist in residence — the first position of its kind in the nation.
- 1933 – College helps Oneida County develop the nation’s first rural zoning ordinance, which served as a national model.
- 1936 – Dairy foods researchers adapt irradiation process to increase vitamin D content of milk.
- 1939 – College establishes world’s first department of wildlife management, headed by Aldo Leopold.
- 1938 – Geneticist Joshua Lederberg discovers sexual reproduction of bacteria. Wins Nobel prize for this work 10 years later.
- 1941 – After a farmer brought to campus a bucket of blood and asked scientists why his cows were bleeding to death, biochemist Karl Paul Link discovered a powerful anticoagulant in spoil sweet clover. He goes on to synthesize various forms of dicumarol, a blood-thinning agent that’s used to treat blood clots and is the basis for Warfarin, a potent rodent killer. The university earned millions from the patents.
- 1941 – Biochemist Henry Lardy devises technique to preserve and store bull semen, making artificial insemination of livestock practical and laying the foundation for the artificial breeding industry and the genetic improvement of dairy cattle herds.
- 1942 – Scientists begin work on mass penicillin production, developing techniques that made a once prohibitively expensive drug affordable and widely available. It was used to treat infections of soldiers injured in World War II.
- 1948 – College crop scientists collaborated on irrigation research that helps makes Wisconsin’s Central Sands — once considered a windblown wasteland — one of the nation’s leading vegetable production areas.
- 1952 – Forage breeders release Vernal alfalfa, a winter-hardy, disease-resistant, high-yielding variety that forms the foundation of Wisconsin’s $10-billion-a-year forage industry.
- 1969 – CALS wildlife ecologist plays pivotal role in defining environmental impacts of organochlorine pesticides. Wisconsin hearings on DDT set the stage for nationwide ban.
- 1970 – Biochemist Har Gobind Khorana synthesizes the first gene. His work leading to this achievement earned him a share of the Nobel Prize in 1968.
- 1977 – CALS bacteriologists describe site of nitrogen-fixing enzyme in bacteria and unravel the mechanism by which the enzyme is regulated — an important step in long-time research aimed at putting nitrogen-fixing capability into non-legume plants.
- 1979 – CALS food safety researchers provide purified botulinum toxin for first trials with human volunteers. Purified toxin made at CALS was the first to be FDA-approved for use in a revolutionary eye treatment that replaced conventional eye surgery. Botulinum toxin is now also used to treat severe neck cramps, cerebral palsy and migraine headaches — as well as to erase wrinkles.
- 1980 – CALS horticulturists clone a plant gene for the first time.
- 1981 – The first transgenic plant (bean protein in sunflowers) demonstrates the potential for genetic engineering in plants.
- 1986 – Horticulturist Brent McCown is first to insert a gene for herbicide resistance in to a woody plant and the first to regenerate a woody plant from a single leaf cell.
- 1997 – Geneticist Fred Blattner decodes the complete genetic sequence of a harmless strain of the E. coli bacterium, leading to a better understanding of its lethal counterpart.
- 1998 – Biochemist Ron Raines discovers the key to collagen’s strength, a protein that acts like a “solder” to give the body its structure and shape.
- 1998 – Microbiologist Jo Handelsman helps pioneer the field of metagenomics, opening the door for scientists to study the genes of large populations of “unculturable” microbes living in soil and other environments.
- 1999 – Biochemist David Schwartz sequences a bacterial genome using shotgun optical mapping, an approach he developed that takes a fraction of the time that conventional DNA sequencing takes.
- 2002 – Biochemists James Ntambi and Alan Attie help discover a gene, known as SCD-1, that appears to play a critical role in fat metabolism. When the gene is removed from mice, the animals can eat a rich, high-fat diet without adding weight or risking the complications of diabetes.
- 2003 – The U.S. Department of Agriculture bestows its prestigious “Secretary’s Honor Award” on the Eco-Potato Partnership, a group composed of the World Wildlife Fund, Wisconsin potato growers and CALS researchers. The award recognizes the team’s efforts to develop and implement more sustainable methods to grow potatoes. Eco-potatoes are now a model for other sustainably-grown produce.
- 2004 – A team led by geneticist Jiming Jiang is the first to sequence a centromere from a higher organism. Although it is widely believed that this section of the chromosome is full of “junk DNA,” Jiang finds more than a handful of active genes in it.
- 2006 – Microbiologist Cameron Currie discovers that leaf-cutting ants harbor bacteria inside specialized compartments in their bodies. The ants use the bacteria, which produce antibiotics, to ward off fungi that invade their food source. The ants also feed the bacteria, making the arrangement a classic example of a mutually-beneficial symbiotic relationship.
- 2008 – Nutritional scientist Denise Ney conducts clinical trials showing that glycomacropeptide, a protein isolated from cheese whey, is safe for people with phenylketonuria to eat. Generally, individuals with PKU must avoid dietary protein, which acts like a toxin inside their bodies.
- 2009 – With virologist Ann Palmenburg as lead author, a multi-institutional team of researchers reports the sequences for all 99 strains of the common cold virus.
- 2010 – In a study that promises to fill in the fine details of the plant world’s blueprint for surviving drought, a team of lead by CALS biochemist Michael Sussman identifies in living plants the set of proteins that help them withstand water stress.
- 2013 – A team led by biochemist Ann Palmenberg constructed a 3-D model of Rhinovirus C, one type of common cold virus. With the new structure in hand – alongside the existing models of cold virus strains A and B – it’ll be easier to design drugs to effectively thwart colds.
- 2014 – Researchers start engineering easy-to-digest poplar trees, applying an approach developed by biochemist John Ralph to create a more energy- and cost-efficient way of converting biomass into fuel.
- 2015 – A team led by plant geneticist John Doebley discovered a key gene involved in teosinte’s evolution into corn. A single nucleotide change in the teosinte glume architectural gene (tga1) stripped away the hard, inedible casing covering teosinte’s kernels – exposing the edible golden kernels.
- 2017 – The Upper Midwestern Center of Excellence in Vector Borne Diseases, co-led by CALS entomology professor Susan Paskewitz, was established through a $10 million grant from the U.S. Centers for Disease Control and Prevention. The goal of the center is to help stem the spread of disease carried by ticks and mosquitoes.
- 2017 – The Wisconsin Crop Innovation Center is established to help plant scientists develop and improve commercially important plant stocks and methodologies. The 100,000-square-foot plant biotechnology facility was donated to UW–Madison by Monsanto.
- 2018 – A research team including CALS scientists announced they had identified varieties of tropical corn from Oaxaca, Mexico that can acquire nitrogen from the air by cooperating with bacteria. This discovery of nitrogen-fixing corn opens the door to developing commercial corn varieties with a reduced need for fertilizer.
- 2019 – The Dairy Innovation Hub is established, a state-supported effort to expand research and teaching at Wisconsin’s three agricultural colleges (including CALS) with the goal of developing new technologies and approaches to strengthen the state’s dairy industry and the communities that depend upon it.
- 2020 – UW–Madison was selected by the National Institutes of Health as the site of a new national research and training hub for cryo-electron microscopy and tomography. The hub will overseen by CALS’ Department of Biochemistry and the Morgridge Institute.